Actinomycin Biosynthesis
نویسندگان
چکیده
منابع مشابه
Biosynthesis of Actinomycin Chromophore
substance was also hydrolyzed lvith acid to split vinyl ethers (13). The products were partitioned between ether and water and cr-glycols determined in each phase. Saponification released considerable amounts of glycerol (Table I, 3b). Thus Eluate C1 from the silicic acid column apparently still contained some ester triglycerides. The ether-soluble fraction contained glycols which yielded on ac...
متن کاملControlled biosynthesis of actinomycin with sarcosine.
Henschler, D. (1956). Hoppe-Seyl. Z. 305, 97. Henschler, D. (1957). Hoppe-Seyl. Z. 309, 276. Hestrin, S. (1949). J. biol. Chem. 180, 249. Hestrin, S. (1950). Biochim. biophys. Acta, 4, 310. Holtz, P. & Schumann, H. G. (1954). Naturwissen8chaften, 41, 306. Kalckar, H. M. (1947). J. biol. Chem. 167, 461. Kaplan, N. 0. & Lipmann, F. (1948). J. biol. Chem. 174,37. Kennedy, E. P. (1956). Canad. J. B...
متن کامل3-Hydroxy-4-methylkynurenine as an intermediate in actinomycin biosynthesis.
tryptophan1.2). The formation of 3-hydroxy-4-methylanthranilic acid probably involves a diversion of the well-known metabolic pathway leading to the formation of 3-hydroxyanthranilic acid from L-tryptophan2). However, the mechanismof transmethylation of the aromatic ring has not been examined to the extent of determining which of the alternative compounds mentioned in Fig. 1 is the pentultimate...
متن کاملInhibition by actinomycin D of oxidation-dependent biosynthesis in Sarcoma 37 ascites cells.
When Sarcoma 37 ascites cells were incubated in the presence of actinomycin D, protein synthesis was inhibited. The inhibitory effect could be prevented or relieved by glucose or by a variety of glycolyzable substrates. The inhibitory effect was independent of the concentration of the labeled amino acid precursor. Under conditions inhibitory to protein synthesis, no significant inhibition of re...
متن کاملBranched-chain amino acid substitutions in the biosynthesis of the antibiotic actinomycin.
Actinomycins normally contain N-methyl-l-valine and either d-valine, d-alloisoleucine or both amino acids in the molecule. During antibiotic formation in a medium supplemented with one of the four isoleucine stereoisomers, Streptomyces parvulus and S. chrysomallus form complex actinomycin mixtures (C(1), C(2), C(3), E(1), and E(2)-like compounds). Although chromatographic techniques suggested t...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1965
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)97288-1